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translocations or amplifications on top of the genomic alterations currently present in the initial CLL, but lack the common mutations observed in primary DLBCL indicating which they could correspond to another biological group.
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).82,eighty three Patients with MBL with mutated motorists Have a very shorter time for you to initial treatment method compared to cases with out mutations. The moment CLL is recognized, the growth dynamics of tumor cells is heterogeneous. Some sufferers show a logistic-like behavior by which the clone stabilizes over time, whereas some Some others exhibit an exponential- like expansion pattern.84 This exponential growth, clinically defined as “short lymphocyte doubling time” remains to be regarded an adverse prognostic parameter in CLL.
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